Sterilizing-Grade PES Filters (0.45 μm / 0.2 μm)
Alioth Alipore® ZHC 0.45/0.2 μm series filters incorporate Alioth self-developed dual-layer asymmetric hydrophilic PES (polyethersulfone) membrane. The 0.45 μm prefiltration layer effectively increases dirt-holding capacity, while the final 0.2 μm layer ensures reliable bacterial retention.
Product Introduction
Alipore® EZ Sterilizing-Grade Filter with Alioth Membranes
The Alipore® EZ Series represents a new generation of sterilizing-grade filters developed using Alioth’s proprietary membrane technology. "EZ," derived from "Easy," signifies our commitment to providing customers with more effortless and confident solutions across three key dimensions: filtration efficiency, operational experience, and risk control.
Three Core Advantages to Address Process Pain Points
1. Higher Efficiency: High Throughput & High Capacity
Multi-layer Asymmetric Membrane Pore Structure | Reliable Bacterial Retention Performance
The multi-layer highly asymmetric membrane pore structure enhances both dirt-holding capacity and throughput, allowing for the processing of larger feed volumes and saving filtration time. This effectively shortens the filtration cycle and boosts overall production efficiency.
Multi-layer highly asymmetric pore structure, balancing high throughput and reliable bacterial retention.
Real feed testing data demonstrates that its dirt-holding capacity and throughput significantly exceed those of imported products.
2. Greater Convenience: No Pre-wetting Needed for Sterilization
Simplified Sterilization Procedures | Lower Risk of Integrity Test Failures
With stable hydrophilicity and wettability, the filters can be sterilized without pre-wetting, simplifying the sterilization process and reducing the risk of integrity test failures.
In traditional sterilization processes, the pre-wetting step not only increases operational time but can also lead to differential pressure issues due to inadequate wetting, thereby elevating the risk of filter damage. The Alipore® EZ Series supports direct sterilization, resulting in a shorter process and more controllable risks, making it particularly suitable for scenarios requiring PUPSIT (Pre-use Post-sterilization Integrity Testing).
Passed bacterial retention and integrity tests after 50 consecutive SIP cycles at 135°C without pre-wetting.
Maintained stable wettability (verified by bubble point and diffusive flow data) after continuous drying at 80°C for 7 days.
3. Ultimate Confidence: Low Protein Absorption
Media Filtration Without Compromising Cell Growth | Final Sterile Filtration Without Fear of Protein Loss
With reliable bacterial retention, sterile filtration is more reassuring. The low protein absorption mitigates the risk of losing critical components during cell culture media filtration and minimizes the absorption loss of precious feedstocks during final sterile filtration.
Protein absorption levels are significantly lower than those of mainstream PES membranes on the market, comparable to PVDF membranes.
Does not affect cell growth status after filtering CHO cell culture media.
Versatile Applications: The EZ Series Excels In
Cell culture media filtration
Final Formulations filtration
Buffers filtration
Intermediates filtration
For more product details, please contact us atmarketing@aliothbio.com.