Peptides

Peptides

To maximize yield of high-value peptide drugs, Alioth's low-adsorption sterile filtration products deliver reliable sterility while minimizing product loss

Peptides

Peptide drugs combine the precision of small-molecule drugs with the activity and specificity of large-molecule biologics, demonstrating enormous potential in metabolic diseases, oncology, and infectious diseases, and representing a major direction in innovative drug R&D.

Alioth's depth filtration and sterile filtration solutions offer outstanding particle retention and microbial removal efficiency, effectively removing insoluble particles, colloids, and microorganisms from peptide solutions — ensuring that peptide drug substances and dosage forms meet the highest standards of purity and safety and comply with stringent pharmacopeial requirements.

Process Map

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Anion / Cation Exchange Chromatography

Anion / Cation Exchange Chromatography

Diafiltration (DF) - Secondary Clarification

Diafiltration (DF) - Secondary Clarification

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Low-pH Incubation

Low-pH Incubation

Affinity Chromatography

Affinity Chromatography

Sterile Filtration (0.22 μm)

Sterile Filtration (0.22 μm)

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Hydrophobic Interaction Chromatography

Hydrophobic Interaction Chromatography

Virus Removal Filtration (20 nm)

Virus Removal Filtration (20 nm)

Ultrafiltration / Diafiltration (UF/DF)

Ultrafiltration / Diafiltration (UF/DF)

Sterile Filtration (0.22 μm)

Sterile Filtration (0.22 μm)

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Formulation & Final Filling

Formulation & Final Filling

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