Recombinant Proteins
Recombinant protein drugs, produced through genetic engineering, offer exceptional specificity and proven efficacy in treating cancer, metabolic disorders, and viral infections — making them one of the fastest-growing sectors in pharmaceuticals. The complexity of feed streams from diverse host expression systems poses significant challenges to filtration process compatibility.
Across diverse recombinant protein expression systems, filtration is key to ensuring process robustness. Alioth filtration solutions are widely applied in fermentation broth clarification, sterile filtration of process fluids (culture media, buffers), microbial control of intermediates, and fermentation gas filtration — ensuring target protein purity and sterility assurance throughout the entire process.
Process Flow
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Cell Line Development

CCM Hydration
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CCM Prefiltration
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CCM Sterile Filtration
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Fermentation
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Virus Inactivation

Affinity Chromatography

Bioburden Reduction
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Secondary Clarification/Depth Filtration
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Primary Clarification/Depth Filtration
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Clarification/Depth Filtration
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Bioburden Reduction
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Anion Chromatography

Bioburden Reduction
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Cation Chromatography

Sterile Filtration
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mAb Substance

Bioburden Reduction
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Ultrafiltration

Virus Removal Filtration

Formulation & Final Filling
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