
Other Applications
For unique process fluids and filtration challenges, Alioth draws on our comprehensive product portfolio and deep technical support to deliver tailored solutions.
Other Applications
Beyond antibodies and ADCs, recombinant proteins, vaccines, CGT, blood products, small-molecule drugs, peptides, and synthetic biology, the biopharmaceutical landscape also encompasses insulin, nucleic acid drugs (e.g., ASOs, siRNA), exosomes, oncolytic viruses, in vitro diagnostics (IVD), and a broad range of novel biological macromolecules.
These emerging sectors are rapidly advancing and impose exceptionally high demands on process flexibility and product safety. Alioth possesses a comprehensive portfolio of filtration solutions, broadly applicable across these products — from cell harvest clarification, endotoxin/pyrogen removal, target molecule purification, through to final sterile filtration — providing reliable, flexible separation and purification support for process development and large-scale manufacturing of innovative biological products.
Process Map

Plasmid Construction

E. coli Plasmid Amplification

Fermentation

Cell Harvest via Hollow Fiber

Alkaline Lysis

Moderate Purification

Crude Purification

Inclusion Body Refolding

Inclusion Body Wash & Solubilization

Centrifugation

Fine Purification

Ultrafiltration

Crystallization & Dissolution

Sterile Filtration

Formulation & Final Filling
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Application Notes

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