Antibodies & ADCs

Antibodies & ADCs

Alioth's high-performance depth and sterile filtration solutions address the demands of large-scale antibody and ADC manufacturing — ensuring consistent yield and reliable sterile assurance.

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Antibodies & ADCs

Antibody drugs — including monoclonal antibodies (mAbs) and bispecific antibodies — and antibody-drug conjugates (ADCs) are the cornerstone of targeted therapy, delivering transformative outcomes in oncology and autoimmune diseases and forming the largest segment of the global biopharmaceutical market.

Throughout the full lifecycle of antibody and ADC drug manufacturing, filtration is the foundation for achieving high yield and high safety. Alioth offers comprehensive filtration solutions spanning fermentation broth clarification, culture media/buffer sterile filtration, bioburden reduction of intermediates, and fermentation gas filtration through to final drug product sterile filtration. Combined with professional process services and technical support, Alioth helps customers achieve high yield, high safety, and superior manufacturing economics for antibody and ADC drugs.

Process Map

Clarification/Depth filtration

Clarification/Depth filtration

Bioburden Reduction

Bioburden Reduction

Anion Chromatography

Anion Chromatography

Bioburden Reduction

Bioburden Reduction

Cation Chromatography

Cation Chromatography

Sterile Filtration

Sterile Filtration

mAb Substance

mAb Substance

Bioburden Reduction

Bioburden Reduction

Ultrafiltration

Ultrafiltration

Virus Removal Filtration

Virus Removal Filtration

Formulation & Final filling

Formulation & Final filling

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