Antibodies & ADCs
Antibody drugs — including monoclonal antibodies (mAbs) and bispecific antibodies — and antibody-drug conjugates (ADCs) are the cornerstone of targeted therapy, delivering transformative outcomes in oncology and autoimmune diseases and forming the largest segment of the global biopharmaceutical market.
Throughout the full lifecycle of antibody and ADC drug manufacturing, filtration is the foundation for achieving high yield and high safety. Alioth offers comprehensive filtration solutions spanning fermentation broth clarification, culture media/buffer sterile filtration, bioburden reduction of intermediates, and fermentation gas filtration through to final drug product sterile filtration. Combined with professional process services and technical support, Alioth helps customers achieve high yield, high safety, and superior manufacturing economics for antibody and ADC drugs.
Process Map
Purple nodes are clickable and lead to Alioth solutions. Gray nodes are informational only.

Cell Line Development

CCM Hydration
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CCM Prefiltration
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CCM Sterile Filtration
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Fermentation
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Virus Inactivation

Affinity Chromatography

Bioburden Reduction
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Secondary Clarification/Depth filtration
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Primary Clarification/Depth Filtration
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Clarification/Depth filtration
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Bioburden Reduction
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Anion Chromatography

Bioburden Reduction
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Cation Chromatography

Sterile Filtration
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mAb Substance

Bioburden Reduction
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Ultrafiltration

Virus Removal Filtration

Formulation & Final filling
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Application Notes
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Scalability Studies for Alioth Alidep® Depth Filters
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