
Antibodies & ADCs
Alioth's high-performance depth and sterile filtration solutions address the demands of large-scale antibody and ADC manufacturing — ensuring consistent yield and reliable sterile assurance.
Antibodies & ADCs
Antibody drugs — including monoclonal antibodies (mAbs) and bispecific antibodies — and antibody-drug conjugates (ADCs) are the cornerstone of targeted therapy, delivering transformative outcomes in oncology and autoimmune diseases and forming the largest segment of the global biopharmaceutical market.
Throughout the full lifecycle of antibody and ADC drug manufacturing, filtration is the foundation for achieving high yield and high safety. Alioth offers comprehensive filtration solutions spanning fermentation broth clarification, culture media/buffer sterile filtration, bioburden reduction of intermediates, and fermentation gas filtration through to final drug product sterile filtration. Combined with professional process services and technical support, Alioth helps customers achieve high yield, high safety, and superior manufacturing economics for antibody and ADC drugs.
Process Map

Virus Inactivation

Affinity Chromatography

Bioburden Reduction

Secondary Clarification/Depth filtration

Primary Clarification/Depth Filtration

Clarification/Depth filtration

Bioburden Reduction

Anion Chromatography

Bioburden Reduction

Cation Chromatography

Formulation & Final filling
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