In biotech and pharma process development, depth filterability studies form the foundation of depth filtration processes. Different depth filtration strategies may be required depending on factors such as fermentation type, cell density, cell viability, initial turbidity, and specific process requirements.
Product Description
Alidep® depth filters are specifically designed for high-demand clarification applications in biotechnology and pharmaceutical processing, offering tailored solutions for a wide range of applications.
The Alidep® product line features various media combinations, primarily consisting of cellulose, filter aids, and positively charged resins. With high dirt-holding capacity, these filters are designed for clarifying cell culture fluids by progressive retention of intact cells and cell debris, turbidity reduction, and efficient adsorption of impurities such as DNA, HCP, and endotoxins, thereby reducing burden on downstream purification steps.
Laboratory-Scale Depth Filter Diagram
The left port labeled “IN” indicates the inlet, while the right port labeled “VENT” is the vent port.
Figure 1-1: Upstream side of the filter.
Figure 1-2: Downstream side showing the filtrate outlet.
Depth Filtration – Filter System Configuration
Figure 2: Single-stage depth filter setup
Figure 3: Two-stage depth filter setup
Select optimal depth filtration setups—filter type, size, and single/dual-stage design—based on feed properties and process needs. Initial system configurations can be experience-based, then refined experimentally.
For more information, please contact us. Alioth delivers customized technical service solutions engineered for your unique process requirements!