In pharmaceutical manufacturing, membrane filters play an indispensable and versatile role. Filters with different performance characteristics can meet various application requirements, ensuring the safety and efficiency of the pharmaceutical process.
Specifically, buffers used in purification stages are typically non-fouling solutions; therefore, filters with higher flow rates are generally recommended. Conversely, solutions containing easily fouling particles, such as culture media, usually require filters with higher capacity.
In this issue of Alidep’s “Insights from the Core” knowledge series, we summarize the factors affecting filtration performance in a single infographic for your reference and learning!
Comprehensive Pharmaceutical Filtration Process Solutions
Alidep provides comprehensive pharmaceutical filtration process solutions, covering depth filtration, pre-filtration, sterilizing-grade filtration, filtration hardware, and laboratory filtration series. With a diverse product portfolio and a wide range of sizes and specifications, we meet the needs of various pharmaceutical processes and are committed to building a safety barrier for drug manufacturing.
• Clarification of CHO cell culture broth
• Clarification in vaccine manufacturing processes
• Clarification of yeast fermentation broth (post-centrifugation)
• Clarification in plasmid manufacturing processes (E. coli lysate)
• Clarification of lentivirus and adeno-associated virus (AAV) culture broth
• Clarification of other complex feed streams
• Clarification of cell culture broth
• Clarification in vaccine manufacturing processes
• Clarification of yeast fermentation broth
• Clarification of other feed streams
Alipore® DHC High-Flow Sterilizing-Grade Hydrophilic PES Filter
• DHC sterilizing-grade cartridge filters: 5”, 10”, 20”, 30”
• DHC Alicap® L-type capsule sterilizing-grade filters: 0.5”, 1”, 2”, 4”, 5”, 10”, 20”
• Hydrophilic polyethersulfone (PES) material
• Liquid sterilizing-grade filtration (0.45 + 0.2 μm)
• Product Features: High flow rate, high capacity; reliable bacterial retention
• Typical Applications: Buffer filtration, filtration of clarified cell culture broth, intermediate and bulk drug substance filtration, sterilizing-grade filtration of final products
Alisafe® TCHF Sterilizing-Grade Hydrophobic PTFE Gas Filter
• TCHF sterilizing-grade cartridge filters: 5”, 10”, 20”, 30”
• Hydrophobic polytetrafluoroethylene (PTFE) material
• Gas and non-aqueous sterilizing-grade filtration (0.2 μm)
• Product Features: High gas throughput, low pressure drop; reliable bacterial retention and particle removal
• Typical Applications: Sterilizing-grade filtration of N₂, O₂, CO₂, and compressed air; vent filters for fermenters and storage tanks; sterilizing-grade filtration of organic solvents