What Does the "Heart" of Biopharmaceuticals Need?
In the precision system of biopharmaceutical manufacturing, fluid transfer is like the "heartbeat" of life — it must be precise, stable, and absolutely clean. The limitations of traditional peristaltic pumps and centrifugal pumps in terms of shear force, pulsation, and cleaning dead legs have become bottlenecks for process scale-up and product consistency improvement.
Recently, Alioth Biotech officially launched the AliFit® High-Precision Diaphragm Pump. It is not merely a pump, but a complete fluid handling solution purpose-built for cGMP aseptic processes. With advantages including low shear, low pulsation, high precision, aseptic-grade design, self-priming capability, and flexible adaptability, AliFit® aims to revolutionize fluid handling standards in bioprocessing.
Why AliFit® High-Precision Diaphragm Pump? Six Core Advantages That Address Process Pain Points
Ultra-Low Shear Force: Lower shear than peristaltic pumps, protecting sensitive bioactive materials (antibodies, cells, vaccines, etc.) from aggregation and inactivation.
Low Pulsation Delivery: Quad-diaphragm design cancels out pulsation, suitable for pressure/flow-sensitive processes such as chromatography, tangential flow filtration (TFF), sterilizing-grade filtration, and virus filtration.
High-Precision Control: Precise flow control with a range from mL-level to m³/h-level, supporting seamless scale-up from R&D to production.
Aseptic-Grade Design: Constructed from 316L stainless steel or single-use PP/TPE materials, compliant with USP <87>/<88>, FDA, and GMP regulatory standards. Supports CIP/SIP and dry running with zero leakage and no particle generation, ensuring aseptic process safety.
Self-Priming Capability: No manual priming required at startup — the pump automatically draws liquid from lower positions and evacuates air from the tubing, establishing normal flow immediately. Ready to use right after bag or bottle changes, simplifying operations and reducing contamination risk.
Flexible Adaptability: Supports quick switching between single-use pump heads (gamma-sterilized) and reusable pump heads (CIP/SIP), meeting multi-scenario and multi-scale requirements.
Full-Spectrum Applications: Throughout the Entire Biopharmaceutical Process
Upstream Cell Culture
Bioreactor Feed/Perfusion: Precisely delivers nutrients and additives for large-scale cultivation (500 L–20,000 L). Ultra-low shear protects cell viability, while low pulsation maintains a stable culture environment.
Seed Train Transfer: Gently transfers cell suspensions to preserve inoculation viability and avoid growth delays.
Downstream Separation & Purification
Chromatography Systems: Delivers samples and buffers for single-column/multi-column systems. Low pulsation ensures chromatographic peak shape and separation reproducibility, while all-stainless-steel pump heads support online cleaning and sterilization.
Tangential Flow Filtration (TFF): Protects product integrity with low shear during antibody/protein concentration and diafiltration, while low pulsation enhances filtration efficiency and consistency.
Formulation & Aseptic Manufacturing
Sterilizing-Grade Filtration & Aseptic Filling: Aseptically transfers injectables, vaccines, and other final products with zero leakage and no particle generation, ensuring the required sterility assurance level.
Single-Use Process Systems: Paired with single-use pump heads to achieve fully closed, cross-contamination-free production — especially suitable for multi-product, high-value biologic manufacturing.
Product Portfolio: Comprehensive Coverage of Your Flow Requirements
Model | Flow Range (L/h) | Key Application Scenarios |
AliFit® DP 30 | 0.9 - 30.0 | Lab R&D, small-scale process development, precious sample handling |
AliFit® DP 100 | 0.3 - 100.0 | Pilot production, clinical sample preparation, small-batch manufacturing |
AliFit® DP 180 | 0.6 - 180.0 | Pilot scale-up, early commercial production |
AliFit® DP 800 | 3.6 - 800.0 | Large-scale upstream cell culture harvest, buffer transfer |
AliFit® DP 1200 | 6.9 - 1200.0 | Large-scale downstream purification, bulk compounding & transfer |
Alioth has always been dedicated to providing trusted filtration process solutions for the pharmaceutical industry. The birth of the AliFit® High-Precision Diaphragm Pump stems from our deep understanding of process pain points and our relentless pursuit of technical excellence. We firmly believe that this innovative product — combining high precision, ultra-low shear, low pulsation, aseptic-grade design, and self-priming capability — will become your reliable partner in improving process efficiency, ensuring product quality, and accelerating project timelines.
Contact us now for a tailored solution!
Email: marketing@aliothbio.com