New Product Launch
In biopharmaceutical manufacturing, sterile filtration serves as the ultimate safeguard for product quality and safety. Facing the practical challenges of complex feed compositions, large batch processing volumes, and increasingly stringent regulatory requirements, process engineers are highly focused on how to balance filtration efficiency, operational convenience, and reliable bacterial retention.
Today, we are proud to present the ultimate solution—the Alipore®EZ Sterilizing-Grade Filter with Alioth Membranes.
Grounded in membrane innovation and driven by real-world process needs, we are making sterile filtration easier than ever.
Alipore® EZ Sterilizing-Grade Filter with Alioth Membranes
The Alipore® EZ Series represents a new generation of sterilizing-grade filters developed using Alioth’s proprietary membrane technology. "EZ," derived from "Easy," signifies our commitment to providing customers with more effortless and confident solutions across three key dimensions: filtration efficiency, operational experience, and risk control.
Three Core Advantages to Address Process Pain Points
1. Higher Efficiency: High Throughput & High Capacity
Multi-layer Asymmetric Membrane Pore Structure | Reliable Bacterial Retention Performance
The multi-layer highly asymmetric membrane pore structure enhances both dirt-holding capacity and throughput, allowing for the processing of larger feed volumes and saving filtration time. This effectively shortens the filtration cycle and boosts overall production efficiency.
Multi-layer highly asymmetric pore structure, balancing high throughput and reliable bacterial retention.
Real feed testing data demonstrates that its dirt-holding capacity and throughput significantly exceed those of imported products.
2. Greater Convenience: No Pre-wetting Needed for Sterilization
Simplified Sterilization Procedures | Lower Risk of Integrity Test Failures
With stable hydrophilicity and wettability, the filters can be sterilized without pre-wetting, simplifying the sterilization process and reducing the risk of integrity test failures.
In traditional sterilization processes, the pre-wetting step not only increases operational time but can also lead to differential pressure issues due to inadequate wetting, thereby elevating the risk of filter damage. The Alipore® EZ Series supports direct sterilization, resulting in a shorter process and more controllable risks, making it particularly suitable for scenarios requiring PUPSIT (Pre-use Post-sterilization Integrity Testing).
Passed bacterial retention and integrity tests after 50 consecutive SIP cycles at 135°C without pre-wetting.
Maintained stable wettability (verified by bubble point and diffusive flow data) after continuous drying at 80°C for 7 days.
3. Ultimate Confidence: Low Protein Absorption
Media Filtration Without Compromising Cell Growth | Final Sterile Filtration Without Fear of Protein Loss
With reliable bacterial retention, sterile filtration is more reassuring. The low protein absorption mitigates the risk of losing critical components during cell culture media filtration and minimizes the absorption loss of precious feedstocks during final sterile filtration.
Protein absorption levels are significantly lower than those of mainstream PES membranes on the market, comparable to PVDF membranes.
Does not affect cell growth status after filtering CHO cell culture media.
Versatile Applications: The EZ Series Excels In
Cell culture media filtration
Final Formulations filtration
Buffers filtration
Intermediates filtration
Exhibition Highlights
Beyond Sterile Filtration: Expert Virus Removal as Well
Ali-ViroClear™ Virus Removal Membranes & Filters: Global Debut
During the Alioth Special Forum at the CPIC conference, Alioth held the global debut ceremony for its proprietary virus removal membranes and sterile filters. The unveiling of the Ali-ViroClear™ Virus Removal Filters alongside the Alipore® EZ Series sterilizing-grade filter marks a new milestone for Alioth, advancing into a dual-track era of "sterile filtration + virus removal" in bioprocessing.
The Ali-ViroClear™ Virus Removal Filter resolves the industry pain point where traditional single-layer membranes struggle to balance throughput/dirt-holding capacity with virus retention efficiency. Beta testing (conducted in actual pharmaceutical manufacturing environments) across more than 20 customers has provided multiple validations of the Ali-ViroClear™ membrane's performance, with results surpassing those of top international products in the majority of projects.
Centered on proprietary membrane technology, Alioth is building a more comprehensive filtration solution portfolio, expanding from sterile to virus removal.
Global Debut of Alioth Proprietary Virus Removal Membranes & Sterile Filters
Ali-ViroClear™ Disc Virus Removal Filter (In Development)
Ali-ViroClear™ Pilot-scale Virus Removal Filter (In Development)
Proprietary Membranes: From "Usable" to "Superior"
From relying on imports to mastering core membrane formulations and casting processes, and from sterile membranes to virus removal membranes—Alioth is responding to the biopharmaceutical industry's deep-seated needs for supply chain security and process autonomy with a complete portfolio of proprietary membrane products.
We are making both sterile and virus removal filtration effortless.
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Contact us now for a customized solution!
Email: marketing@aliothbio.com