0.2 μm Sterilizing-Grade PTFE Gas Filters
The Alioth Alisafe® TCHF Series utilizes a hydrophobic and chemically inert PTFE (polytetrafluoroethylene) membrane. Through rigorous liquid bacteria retention validation, this product effectively retains microorganisms and particles in wet or humid gas streams. Engineered for high strength, it withstands multiple steam-in-place (SIP) sterilization cycles.
The TCHF Series is ideal for sterile gas filtration and the filtration of organic solvents with stringent quality requirements in pharmaceutical applications.
Key Features and Benefits
Natural hydrophobic material
High gas flux and low-pressure drop
Reliable bacterial/particles removal efficiency
Excellent chemical compatibility
Resistance to multiple steam sterilization
Typical Applications
Bioreactors (inlet | outlet)
Storage tank venting
Filling equipment venting
Lyophilizer
Autoclave venting
Sterile filtration of organic solvents
Product Specifications
Alicap® Capsule Filters
| Product Specifications | L300 | L600 | L02 | L04 | L3 | L5 | L10 | L20 | L30 | T10 | T20 | T30 | |
| Body Diameter | 67 mm | 67 mm | 72 mm | 72 mm | 97 mm | 92 mm | 92 mm | 92 mm | 92 mm | 92 mm | 92 mm | 92 mm | |
| Maximum Width | 75 mm | 75 mm | 97 mm | 97 mm | 128 mm | 132 mm | 132 mm | 132 mm | 132 mm | 132 mm | 132 mm | 132 mm | |
| Maximum Length | 98.5 mm | 120 mm | 161 mm | 214 mm | 170 mm | 211 mm | 330 mm | 575 mm | 830 mm | 350 mm | 596 mm | 851 mm | |
| Materials of Construction | Membrane | Polytetrafluoroethylene (PTFE) | |||||||||||
| Supporting Layer | Polypropylene (PP) | ||||||||||||
| O-rings | Silicone | ||||||||||||
| Core/Cage/End caps/Housing | Polypropylene (PP) | ||||||||||||
| Integrity Testing | Bubble Point | ≥1300 mbar（18.9 psi）(wetted with 60% IPA, 20℃, compressed air) | |||||||||||
| Diffusion Flow(mL/min) | Test pressure 1040 mbar (15 psi)（wetted with 60% IPA, 20℃, compressed air ） | ||||||||||||
| ≤ 0.75 | ≤ 1.5 | ≤ 3 | ≤ 4 | ≤ 4.5 | ≤ 6.5 | ≤ 13 | ≤ 26 | ≤ 39 | ≤ 13 | ≤ 26 | ≤ 39 | ||
| Water Intrusion(mL/min) | Test pressure 2500 mbar (36 psi) （20℃, compressed air ） | ||||||||||||
| ≤ 0.03 | ≤ 0.05 | ≤ 0.1 | ≤ 0.15 | ≤ 0.17 | ≤ 0.25 | ≤ 0.5 | ≤ 1 | ≤ 1.5 | ≤ 0.5 | ≤ 1 | ≤ 1.5 | ||
| Working Characteristics | Maximum Differential Pressure | Forward: 5.5 bar（79.8 psi）@ 25℃/3.0 bar（43.5 psi）@ 80℃ | |||||||||||
| Reverse: 4.0 bar（58.0 psi）@ 25℃/1.0 bar（14.5 psi）@ 80℃ | |||||||||||||
| Sterilization Resistance | Alicap® L300/L600/L02/L04/L3： Autoclave(A): 135℃, 30 min, 30 cycles *Capsule filters can't be sterilized by SIP, sterile type capsule filters can't be sterilized again | Alicap® L5/L10/L20/L30/T10/T20/T30： Autoclave(A): 135℃, 30 min, 50 cycles *Capsule filters can't be sterilized by SIP, sterile type capsule filters can't be sterilized again | |||||||||||
| Effective Filtration Area | 260cm2 | 480 cm2 | 0.1 m2 | 0.2 m2 | 0.22 m2 | 0.33 m2 | 0.65 m2 | 1.3 m2 | 1.95 m2 | 0.65 m2 | 1.3 m2 | 1.95 m2 | |
| Pore Size | 0.2 μm | ||||||||||||
| Bacterial Retention | ﹥10^7 cfu/cm2 B. diminuta ( ATCC® 19146TM ) | ||||||||||||
| Biological Safety | All construction components meet the biological safety requirements refering to USP<88> Class VI plastic and USP<87> | ||||||||||||
| Indirect Food Additive | All component materials meet the requirements of Indirect Food Additive cited in EU 1935/2004/EC and FDA 21 CFR 177-182 | ||||||||||||
| Cleanliness | Meets the requirements for a 'non-fiber releasing' filter defined in FDA 21 CFR 211.72 and 210.3 (b) (5) (6), and particulate matter meets the requirements of USP<788> | ||||||||||||
| Endotoxin | Endotoxin﹤0.25 EU/mL by LAL test method, which complies with the requirements of USP<85> | ||||||||||||
| Manufacturing Integrity | 100% integrity test passed | ||||||||||||
| Manufacturing Environment | Manufactured in conformance with cGMP | ||||||||||||
Cartridge Filters
| Product Specifications | 5 inch | 10 inch | 20 inch | 30 inch | |
| Diameter | 69 mm | 69 mm | 69 mm | 69 mm | |
| Maximum Length | 155 mm | 318 mm | 566 mm | 813 mm | |
| Materials of Construction | Membrane | Polytetrafluoroethylene (PTFE) | |||
| Supporting Layer | Polypropylene (PP) | ||||
| O-rings | Silicone, Ethylene propylene diene monomer(EPDM), FEP/PFA encapsulated O-rings | ||||
| Core/Cage/End caps/Adaptor | Polypropylene (PP) | ||||
| Integrity Testing | Bubble Point | ≥1300 mbar（19 psi）(wetted with 60% IPA, 20℃, compressed air) | |||
| Diffusion Flow | Test pressure 1040 mbar (15 psi)（wetted with 60% IPA, 20℃, compressed air ） | ||||
| ≤6.5 mL/min | ≤13 mL/min | ≤26 mL/min | ≤39 mL/min | ||
| Water Intrusion(mL/min) | Test pressure 2500 mbar (36 psi) （20℃, compressed air ） | ||||
| ≤0.25 mL/min | ≤0.5 mL/min | ≤1.0 mL/min | ≤1.5 mL/min | ||
| Working Characteristics | Maximum Differential Pressure | Forward: 7.0 bar（101.5 psi）@ 25°C/3.0 bar（43.5 psi）@ 80°C Reverse: 4.0 bar ( 58.0 psi）@ 25℃/1.0 bar ( 14.5 psi）@ 80°C | |||
| Sterilization Resistance | Steam-In-Place at 142℃ for 30 min, 150 cycles (100 forward cycles plus 50 reverse cycles) Autoclave at 135℃ for 30 min, 200 cycles | ||||
| Effective Filtration Area | 0.33 m2 | 0.65 m2 | 1.3 m2 | 1.95 m2 | |
| Pore Size | 0.2 μm | ||||
| Bacterial Retention | ﹥10^7 cfu/cm2 B. diminuta ( ATCC® 19146TM ) | ||||
| Biological Safety | All construction components meet the biological safety requirements refering to USP<88> Class VI plastic and USP<87> | ||||
| Indirect Food Additive | All component materials meet the requirements of Indirect Food Additive cited in EU 1935/2004/EC and FDA 21 CFR 177-182 | ||||
| Cleanliness | Meets the requirements for a 'non-fiber releasing' filter defined in FDA 21 CFR 211.72 and 210.3 (b) (5) (6), and particulate matter meets the requirements of USP<788> | ||||
| Endotoxin | Endotoxin﹤0.25 EU/mL by LAL test method, which complies with the requirements of USP<85> | ||||
| Manufacturing Integrity | 100% integrity test passed | ||||
| Manufacturing Environment | Manufactured in conformance with cGMP | ||||
Typical Flow Characteristics
Air Flow Rate and Pressure Drop-Alisafe® TCHF 0.2 μm Cartridge Filters
Ordering Information-Capsule Filters
Connector: Alicap® L300/L600, available with B6 Connector; Alicap® L02/L04, available with T1, T3, B5, B7 Connector; Alicap® L3/L5/L10/L20/L30, available with B4, T1 Connector; Alicap® T10/T20/T30, available with T1 Connector.
Format
- K=L-type Capsule
- T=T-type Capsule
Membrane material
- T=PTFE
Membrane series
- C=C series
Pore size
- 02=0.2 μm
02=0.2 μm
- S2: Alicap® L300
- S3: Alicap® L600
- M1: Alicap® L02
- M3: Alicap® L04
- L3: Alicap® L3
- 5: Alicap® L5
- 1: Alicap® L10
- 2: Alicap® L20
- 3: Alicap® L30
Capsule connector
- T1: 38 mm(1 1/2") Sanitary flange inlet and outlet
- T3: 19 mm(3/4") Sanitary flange inlet and outlet
- B4: 13 mm(1/2") Single-stage hose inlet and outlet
- B5: 9.6 mm(3/8") Multistage hose inlet and outlet
- B6: 7-13 mm(1/4"-1/2") Hose barb inlet and outlet
- B7: 6 mm(1/4") Multistage hose inlet and outlet
O-ring
- S = Silicone
Package
- 1=1/PK
Sterilization
- A=Autoclavable
Ordering Information-Cartridge Filters
Format
- C=Cartridge
Membrane material
- T=PTFE
Membrane series
- C=C series
Pore size
- 02=0.2 μm
Length
- 5=5 inch
- 1=10 inch
- 2=20 inch
- 3=30 inch
Catridge adaptor
- 7=226, Spearhead with fins
- 2=226, Flat end with fins(5 inch)
O-ring
- S=Silicone
- T=EPDM
- B=FEP/PFA encapsulated O-rings
Package
- 1=1/PK
- 3=3/PK(20&30 inch）
Resource Downloads
Alisafe® TCHF Sterilizing-Grade Hydrophobic PTFE Gas Filter.pdf
PDF · 545.82 KB · Published on 2026-05-11
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