HomeProductsLiquid Sterile FiltrationHigh-Throughput Sterilizing-Grade PES Filters (0.2+0.2 μm / 0.45+0.2 μm)
High-Throughput Sterilizing-Grade PES Filters (0.2+0.2 μm / 0.45+0.2 μm)
Alioth Alipore® DHC filters are constructed with a double-layer asymmetric olyethersulfone (PES) membrane, which allow for various combinations of membrane pore sizes to meet the requirements for filtration precision in different applications. The filters are suitable for a variety of sterile filtration of process fluids.
Alipore® DHC filters are validated by strict filtration performance guarantees, with wide chemical compatibility, high flow rate and high capacity to optimize process efficiency and cost effectiveness.
Key Features and Benefits
Reliable bacterial retention performance
High flux and high capacity
100% integrity test passed
Consistent scale-up performance from lab to commercial manufacturing
Typical Applications
Culture media filtration
Buffer filtration
Intermediate product filtration
Final fill filtration
Product Specifications
Alidisk® Disc Filters
| Product Specifications | Size (Diameter) | 50 mm |
| Materials of Construction | Membrane | Hydrophilic polyethersulfone (PES) |
| Supporting Layer/ Housing | Polypropylene (PP) | |
| Integrity Testing | Bubble Point | ≥ 3520 mbar（51 psi）(wetted with H２O, 20℃, compressed air） |
| Working Characteristics | Maximum Differential Pressure | Forward: 5.0 bar（72.5 psi）@ 25°C |
| Sterilization Resistance | Reverse: 1.0 bar（14.5 psi）@ 25°C | |
| Sterilization Resistance | Autoclave(A&G): 125℃, 60 min, 30 cycles Gamma-compatible (G): 25-45 kGy *Presterilized disc filter(s) must not be re-sterilized | |
| Effective Filtration Area | 18 cm2 | |
| Pore Size | 0.2+0.2 μm、0.45+0.2 μm | |
| Bacterial Retention | ﹥10^7 cfu/cm2 B. diminuta ( ATCC® 19146TM ) | |
| Biological Safety | All construction components meet the biological safety requirements refering to USP<88> Class VI plastic and USP<87> | |
| Indirect Food Additive | All component materials meet the requirements of Indirect Food Additive cited in EU 1935/2004/EC and FDA 21 CFR 177-182 | |
| Cleanliness | Meets the requirements for a 'non-fiber releasing' filter defined in FDA 21 CFR 211.72 and 210.3 (b) (5) (6), and particulate matter meets the requirements of USP<788> | |
| Endotoxin | Endotoxin﹤0.25 EU/mL by LAL test method, which complies with the requirements of USP<85> | |
| TOC / Conductivity | TOC﹤0.5 mg/L, Conductivity﹤1.3 μS/cm | |
| Manufacturing Integrity | 100% integrity test passed | |
| Manufacturing Environment | Manufactured in conformance with cGMP |
Alicap® Capsule Filters
| Product Specifications | L300 | L600 | L02 | L04 | L3 | L5 | L10 | L20 | L30 | T10 | T20 | T30 | |
| Body Diameter | 67 mm | 67 mm | 72 mm | 72 mm | 97 mm | 92 mm | 92 mm | 92 mm | 92 mm | 92 mm | 92 mm | 92 mm | |
| Maximum Width | 75 mm | 75 mm | 97 mm | 97 mm | 128 mm | 132 mm | 132 mm | 132 mm | 132 mm | 132 mm | 132 mm | 132 mm | |
| Maximum Length | 98.5 mm | 120 mm | 161 mm | 214 mm | 170 mm | 211 mm | 330 mm | 575 mm | 830 mm | 350 mm | 596 mm | 851 mm | |
| Materials of Construction | Membrane | Hydrophilic polyethersulfone (PES) | |||||||||||
| Supporting Layer | Polypropylene (PP) | ||||||||||||
| O-rings | Silicone | ||||||||||||
| Core/Cage/End caps/Housing | Polypropylene (PP) | ||||||||||||
| Integrity Testing | Bubble Point | ≥3800 mbar (55.1 psi) (wetted with H2O, 20℃, compressed air) (0.2+0.2 μm) | |||||||||||
| ≥3520 mbar (51 psi) (wetted with H2O, 20℃, compressed air) (0.45+0.2 μm) | |||||||||||||
| Diffusion Flow | Test pressure 3000 mbar (43.5 psi) (20℃, compressed air), ≤25 mL/min @10 inch (0.2+0.2 μm) | ||||||||||||
| Test pressure 2760 mbar (40 psi) (20℃, compressed air), ≤25 mL/min @10 inch (0.45+0.2 μm) | |||||||||||||
| Working Characteristics | Maximum Differential Pressure | Forward: 5.0 bar（72.5 psi）@ 25°C/3.0 bar（43.5 psi）@ 80°C | |||||||||||
| Reverse: 3.0 bar（43.5 psi）@ 25°C/1.0 bar（14.5 psi）@ 80℃ | |||||||||||||
| Sterilization Resistance | Autoclave(A&G): 131℃, 30 min, 10 cycles Gamma-compatible (G): 25-45 kGy *Capsule filters can't be sterilized by SIP, sterile type capsule filters can't be sterilized again | ||||||||||||
| Effective Filtration Area | 230cm2 | 430 cm2 | 0.11 m2 | 0.19 m2 | 0.18 m2 | 0.28 m2 | 0.55 m2 | 1.1 m2 | 1.65 m2 | 0.55 m2 | 1.1 m2 | 1.65 m2 | |
| Pore Size | 0.2+0.2 μm、0.45+0.2 μm | ||||||||||||
| Bacterial Retention | ﹥10^7 cfu/cm2 B. diminuta ( ATCC® 19146TM ) | ||||||||||||
| Biological Safety | All construction components meet the biological safety requirements refering to USP<88> Class VI plastic and USP<87> | ||||||||||||
| Indirect Food Additive | All component materials meet the requirements of Indirect Food Additive cited in EU 1935/2004/EC and FDA 21 CFR 177-182 | ||||||||||||
| Cleanliness | Meets the requirements for a 'non-fiber releasing' filter defined in FDA 21 CFR 211.72 and 210.3 (b) (5) (6), and particulate matter meets the requirements of USP<788> | ||||||||||||
| Endotoxin | Endotoxin﹤0.25 EU/mL by LAL test method, which complies with the requirements of USP<85> | ||||||||||||
| TOC / Conductivity | TOC﹤0.5 mg/L, Conductivity﹤1.3 μS/cm | ||||||||||||
| Manufacturing Integrity | 100% integrity test passed | ||||||||||||
| Manufacturing Environment | Manufactured in conformance with cGMP | ||||||||||||
Cartridge Filters
| Product Specifications | 5 inch | 10 inch | 20 inch | 30 inch | |
| Diameter | 69 mm | 69 mm | 69 mm | 69 mm | |
| Maximum Length | 155 mm | 318 mm | 566 mm | 813 mm | |
| Materials of Construction | Membrane | Hydrophilic polyethersulfone (PES) | |||
| Supporting Layer | Polypropylene (PP) | ||||
| O-rings | Silicone, Ethylene propylene diene monomer(EPDM), FEP/PFA encapsulated O-rings | ||||
| Core/Cage/End caps/Adaptor | Polypropylene (PP) | ||||
| Integrity Testing | Bubble Point | ≥3800 mbar (55.1 psi) (wetted with H2O, 20℃, compressed air) (0.2+0.2 μm) | |||
| ≥3520 mbar (51 psi) (wetted with H2O, 20℃, compressed air) (0.45+0.2 μm) | |||||
| Diffusion Flow | Test pressure 3000 mbar (43.5 psi) (20℃, compressed air), ≤25 mL/min @10 inch (0.2+0.2 μm) | ||||
| Test pressure 2760 mbar (40 psi) (20℃, compressed air), ≤25 mL/min @10 inch (0.45+0.2 μm) | |||||
| Working Characteristics | Maximum Differential Pressure | Forward: 7.0 bar（101.5 psi）@ 25°C/3.0 bar（43.5 psi）@ 80°C Reverse: 3.0 bar（43.5psi）@ 25°C/1.0 bar (14.5 psi) @ 80℃ | |||
| Sterilization Resistance | Steam-In-Place: 135℃, 30 min, 50 cycles Autoclave: 135℃, 30 min, 50 cycles | ||||
| Effective Filtration Area | 0.28 m2 | 0.55 m2 | 1.1 m2 | 1.65 m2 | |
| Pore Size | 0.2+0.2 μm、0.45+0.2 μm | ||||
| Bacterial Retention | ﹥10^7 cfu/cm2 B. diminuta ( ATCC® 19146TM ) | ||||
| Biological Safety | All construction components meet the biological safety requirements refering to USP<88> Class VI plastic and USP<87> | ||||
| Indirect Food Additive | All component materials meet the requirements of Indirect Food Additive cited in EU 1935/2004/EC and FDA 21 CFR 177-182 | ||||
| Cleanliness | Meets the requirements for a 'non-fiber releasing' filter defined in FDA 21 CFR 211.72 and 210.3 (b) (5) (6), and particulate matter meets the requirements of USP<788> | ||||
| Endotoxin | Endotoxin﹤0.25 EU/mL by LAL test method, which complies with the requirements of USP<85> | ||||
| TOC / Conductivity | TOC﹤0.5 mg/L, Conductivity﹤1.3 μS/cm | ||||
| Manufacturing Integrity | 100% integrity test passed | ||||
| Manufacturing Environment | Manufactured in conformance with cGMP | ||||
Typical Flow Characteristics
Water Flow Rate and Pressure Drop-Alipore® DHC 0.45+0.2 μm Cartridge Filters
Water Flow Rate and Pressure Drop-Alipore® DHC 0.2+0.2 μm Cartridge Filters
Ordering Information-Disc Filters
Format
- D=Disc
Membrane material
- E=PES
Membrane series
- D=D series
Pore size
- 22=0.2+0.2 μm
- 52=0.45+0.2 μm
Length
- 5=Diameter 50 mm
Disc adaptor
- Hose barb inlet and outlet Hose barb inlet and outlet
Package
- 6=6/PK
Sterilization
- A=Autoclavable
- G=Gamma compatible
- S=Sterile
Ordering Information-Capsule Filters
Connector: Alicap® L300/L600, available with B6 Connector; Alicap® L02/L04, available with T1, T3, B5, B7 Connector; Alicap® L3/L5/L10/L20/L30, available with B4, T1 Connector; Alicap® T10/T20/T30, available with T1 Connector.
Format
- K=L-type Capsule
- T=T-type Capsule
Membrane material
- E=PES
Membrane series
- D=D series
Pore size
- 22=0.2+0.2 μm
- 52=0.45+0.2 μm
Length
- S2: Alicap® L300
- S3: Alicap® L600
- M1: Alicap® L02
- M3: Alicap® L04
- L3: Alicap® L3
- 5: Alicap® L5
- 1: Alicap® L10
- 2: Alicap® L20
- 3: Alicap® L30
Capsule connector
- T1: 38 mm(1 1/2") Sanitary flange inlet and outlet
- T3: 19 mm(3/4") Sanitary flange inlet and outlet
- B4: 13 mm(1/2") Single-stage hose inlet and outlet
- B5: 9.6 mm(3/8") Multistage hose inlet and outlet
- B6: 7-13 mm(1/4"-1/2") Hose barb inlet and outlet
- B7: 6 mm(1/4") Multistage hose inlet and outlet
O-ring
- S=Silicone
Package
- 1=1/PK
Sterilization
- A=Autoclavable
- G=Gamma compatible S=Sterile
Ordering Information-Cartridge Filters
Format
- C=Cartridge
Membrane material
- E=PES
Membrane series
- D=D series
Pore size
- 22=0.2+0.2 μm
- 52=0.45+0.2 μm
Length
- 5=5 inch
- 1=10 inch
- 2=20 inch
- 3=30 inch
Catridge adaptor
- 7=226, Spearhead with fins
- 2=226, Flat end with fins(5 inch)
O-ring
- S=Silicone
- T=EPDM
- B=FEP/PFA encapsulated O-rings
Package
- 1=1/PK
- 3=3/PK(20&30 inch)
Resource Downloads
High-Throughput Sterilizing-Grade PES Filters (0.2+0.2 μm/0.45+0.2 μm)
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